Viruses are the simplest of life-forms. Yet, they can cause severe debilitating human illnesses. A shrinking global community means that outbreaks of emerging viral infections are no longer limited by geographies. Understanding how viruses interact with the host cells, how they disassemble to release their genome and assemble into progeny virions, and how they subvert the host cellular innate immune system will not only help develop effective antivirals, but will also help in addressing several basic biological questions..
Our group utilizes a combination of cryo-electron microscopy, molecular dynamic simulations, biochemical and biophysical techniques to decipher the structural, functional and immunological features of macromolecular interactions during viral infections